Two different things - the US regional banks etf is US smaller banks only and the S&P Financials is a sector etf of companies in the S&P 500 financials index, so basically all sorts of different types of companies that come under the heading of financial services. Or in corporate finance speak: (“An index composed of U.S. Financial Sector companies as defined by the Global Industry Classification Standard (GICS)”).
Holdings below or at iShares (same index)

